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Abrams' Clinical Drug TherapyRationales for Nursing Practice

Abrams' Clinical Drug TherapyRationales for Nursing Practice 12th Edition

By: Geralyn Frandsen Sandra S. Pennington
ISBN-10: 1975136136
/ ISBN-13: 9781975136154
Edition: 12th Edition
Language: English
				
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SECTION 1 THE CONCEPTUAL FRAMEWORK OF PHARMACOLOGY

    • 1 The Foundation of Pharmacology: Quality and Safety
    • Introduction
    • Drug Sources
    • Drug Classifications and Prototypes
    • Drug Names
    • Drug Marketing
    • Pharmacoeconomics
    • Pharmacogenomics
    • Access to Drugs
    • Drug Approval Processes: Food and Drug Administration
    • Safety in Drug Administration
    • Sources of Drug Information
    • Strategies for Studying Pharmacology
    • 2 Basic Concepts and Processes
    • Introduction
    • Cellular Physiology
    • Drug Transport Through Cell Membranes
    • Pharmacokinetics
    • Pharmacodynamics
    • Variables That Affect Drug Actions
    • Adverse Effects of Drugs
    • Toxicology: Drug Overdose
    • 3 Medication Administration and the Nursing Process of Drug Therapy
    • Introduction
    • General Principles of Accurate Drug Administration
    • Legal Responsibilities
    • Medication Errors and Their Prevention
    • Medication Orders
    • Drug Preparations and Dosage Forms
    • Calculating Drug Dosages
    • Routes of Administration
    • Nursing Process in Drug Therapy
    • Integrating Evidence-Based Practice With the Nursing Process
    • Herbal and Dietary Supplements

SECTION 2 DRUG THERAPY THROUGHOUT THE LIFESPAN

    • 4 Pharmacology and the Care of Infants and Pediatric Patients
    • Introduction
    • Drug Safety in Pediatrics
    • Pharmacotherapy in Pediatrics
    • Medication Administration in Pediatrics
    • 5 Pharmacology and the Care of Adults and Geriatric Patients
    • Introduction
    • Pharmacodynamics in Older Adults
    • Pharmacokinetics in Older Adults
    • Medication Adherence and Aging
    • 6 Pharmacology and the Care of Pregnant or Lactating Women
    • Introduction
    • Drug Therapy for Infertility
    • Drugs Used in Pregnancy
    • Fetal Therapeutics
    • Maternal Therapeutics
    • Drugs That Alter Uterine Motility: Tocolytics
    • Drugs Used During Labor and Delivery at Term
    • Lactation
    • 7 Pharmacology and Women’s Health
    • Introduction
    • Overview of Reproduction in Women
    • Common Reproductive Health Problems in Women
    • Estrogens
    • Progestins
    • Estrogen–Progestin Combinations
    • 8 Pharmacology and Men’s Health
    • Introduction
    • Overview of Reproductive Health Problems in Men
    • Androgens and Anabolic Steroids
    • Phosphodiesterase Type 5 Inhibitors
    • Adjuvant Medications Used to Treat Erectile Dysfunction
    • Drugs for Benign Prostatic Hypertrophy
    • 5-Alpha Reductase Inhibitors
    • Alpha1-Adrenergic Blockers

SECTION 3 DRUGS AFFECTING THE HEMATOPOIETIC AND IMMUNE SYSTEMS

    • 9 Drug Therapy for Coagulation Disorders
    • Introduction
    • Overview of Coagulation Disorders
    • Anticoagulant Drugs
    • Antiplatelet Drugs
    • Thrombolytic Drugs
    • Drugs Used to Control Bleeding
    • 10 Drug Therapy for Dyslipidemia
    • Introduction
    • Overview of Dyslipidemia
    • HMG-CoA Reductase Inhibitors
    • Bile Acid Sequestrants
    • Fibrates
    • Cholesterol Absorption Inhibitor
    • PCSK9 Inhibitors
    • Miscellaneous Dyslipidemic Agent
    • Combination Therapy Used to Treat Dyslipidemia
    • 11 Drug Therapy for Hematopoietic Disorders
    • Introduction
    • Overview of Hematopoiesis and Immune Function
    • Erythropoiesis-Stimulating Agents
    • Granulocyte Colony-Stimulating Factors
    • Interferons
    • Adjuvant Medications Used to Stimulate the Immune System: Interleukins
    • 12 Drug Therapy: Immunizations
    • Introduction
    • Overview of Immunization
    • Individual Immunizing Agents
    • Keeping Up-to-Date With Immunization Recommendations
    • 13 Drug Therapy to Decrease Immunity
    • Introduction
    • Overview of Altered Immune Function
    • Cytotoxic Immunosuppressive Agents
    • Conventional Antirejection Agents
    • Janus Associated Kinase Inhibitor
    • Adjuvant Medications Used to Suppress Immune Function
    • 14 Drug Therapy for the Treatment of Cancer
    • Introduction
    • Overview of Cancer
    • Cytotoxic Antineoplastic Drugs Used to Treat Cancer
    • Adjuvant Medications Used to Treat Cancer

SECTION 4 DRUGS AFFECTING INFLAMMATION AND INFECTION

    • 15 Inflammation, Infection, and the Use of Antimicrobial Agents
    • Introduction
    • Overview of Inflammation
    • Overview of Microorganisms
    • 16 Drug Therapy to Decrease Pain, Fever, and Inflammation
    • Introduction
    • Overview of Pain, Fever, and Inflammation
    • Specific Conditions
    • Gout
    • Salicylates
    • Nonnarcotic Analgesic Antipyretic: Acetaminophen
    • Nonsteroidal Anti-Inflammatory Drugs
    • Propionic Acid Derivatives
    • Oxicam Derivatives
    • Acetic Acid Derivatives
    • Selective COX-2 Inhibitor: Celecoxib
    • Antigout Medication
    • Uricosuric Agents
    • 17 Drug Therapy With Corticosteroids
    • Introduction
    • Physiology of Endogenous Corticosteroids
    • Pathophysiology of Adrenal Cortex Disorders
    • Drug Therapy with Exogenous Corticosteroids
    • 18 Drug Therapy With Beta-Lactam Antibacterial Agents
    • Introduction
    • Penicillins
    • Cephalosporins
    • Carbapenems
    • Monobactams
    • 19 Drug Therapy With Aminoglycosides and Fluoroquinolones
    • Introduction
    • Aminoglycosides
    • Fluoroquinolones
    • 20 Drug Therapy With Tetracyclines, Sulfonamides, and Urinary Antiseptics
    • Introduction
    • Tetracyclines
    • Sulfonamides
    • Adjuvant Medications Used to Treat Urinary Tract Infections: Urinary Antiseptics
    • 21 Drug Therapy With Macrolides and Miscellaneous Anti-infective Agents
    • Introduction
    • Macrolides
    • Miscellaneous Anti-infective Agents
    • 22 Drug Therapy for Tuberculosis and Mycobacterium Avium Complex Disease
    • Introduction
    • Overview of Tuberculosis and Mycobacterium Avium Complex Disease
    • Isoniazid
    • Rifamycins
    • Adjuvant First-Line Antitubercular Drugs
    • First-Line Drug Combinations Used to Treat Tuberculosis
    • Second-Line Drugs Used to Treat Tuberculosis
    • Drugs Used to Treat Mycobacterium Avium Complex Disease
    • Special Strategies to Increase Adherence to Antitubercular Drug Regimens
    • 23 Drug Therapy for Viral Infections
    • Introduction
    • Overview of Viruses and Viral Infections
    • Drugs for Herpesvirus Infections
    • Drugs for Respiratory Syncytial Virus
    • Monoclonal Antibody for Respiratory Syncytial Virus
    • Drugs for Hepatitis B: Nucleoside Analogs
    • Drugs for Hepatitis C: Polymerase Inhibitors
    • Drugs for Human Immunodeficiency Virus (Antiretroviral Drugs)
    • Protease Inhibitors
    • Cytochrome P-450 Inhibitor
    • Combination Medication for HIV-1: Integrase Inhibitor, Reverse Transcriptase Inhibitor, Nucleoside, Reverse Transcriptase Inhibitor, Nucleotide
    • 24 Drug Therapy for Fungal Infections
    • Introduction
    • Overview of Fungal Infections
    • Polyenes
    • Azoles
    • Echinocandins
    • Miscellaneous Antifungal Agents for Superficial Mycoses
    • Pyrimidine Analog
    • 25 Drug Therapy for Parasitic Infections
    • Introduction
    • Overview of Parasitic Infections
    • Amebicides
    • Antimalarials
    • Anthelmintics
    • Scabicides and Pediculicides

SECTION 5 DRUGS AFFECTING THE CARDIOVASCULAR SYSTEM

    • 26 Drug Therapy for Hypertension
    • Introduction
    • Overview of Hypertension
    • Angiotensin-Converting Enzyme Inhibitors
    • Angiotensin II Receptor Blockers
    • Calcium Channel Blockers
    • Adjuvant Medications Used to Treat Hypertension
    • 27 Drug Therapy for Dysrhythmias
    • Introduction
    • Overview of Dysrhythmias
    • Class I Sodium Channel Blockers
    • Class IA
    • Class IB
    • Class IC
    • Class II Beta-Adrenergic Blockers
    • Class III Potassium Channel Blockers
    • Class IV Calcium Channel Blockers
    • Unclassified Antidysrhythmic Drugs
    • Drug Therapy in Emergency Resuscitation of Adults
    • Magnesium Sulfate
    • 28 Drug Therapy for Coronary Heart Disease
    • Introduction
    • Overview of Coronary Artery Disease
    • Organic Nitrates
    • Beta-Adrenergic Blockers
    • Calcium Channel Blockers
    • Adjuvant Medications
    • 29 Drug Therapy for Shock and Hypotension
    • Introduction
    • Overview of Acute Hypotension and Shock
    • Treatment of Hypotension and Shock
    • Adrenergic Drugs
    • 30 Drug Therapy for Heart Failure
    • Introduction
    • Overview of Heart Failure
    • Cardiac Glycosides
    • Phosphodiesterase Inhibitors (Cardiotonic–Inotropic Agents)
    • Angiotensin Receptor–Neprilysin Inhibitors
    • Sinoatrial Node Modulators
    • Adjuvant Medications Used to Treat Heart Failure

SECTION 6 DRUGS AFFECTING THE RESPIRATORY SYSTEM

    • 31 Drug Therapy for Nasal Congestion and Cough
    • Introduction
    • Overview of Nasal Congestion and Other Respiratory Symptoms
    • Nasal Decongestants
    • Antitussives
    • Expectorants
    • Mucolytics
    • Herbal Remedies and Other Preparations
    • Combination Products
    • 32 Drug Therapy to Decrease Histamine Effects and Allergic Response
    • Introduction
    • Overview of Histamine Release and the Allergic Response
    • First-Generation H1 Receptor Antagonists
    • Second-Generation H1 Receptor Antagonists
    • Third-Generation H1 Receptor Antagonists
    • 33 Drug Therapy for Asthma, Airway Inflammation, and Bronchoconstriction
    • Introduction
    • Overview of Asthma
    • Adrenergics
    • Anticholinergics
    • Xanthines
    • Corticosteroids
    • Leukotriene Modifiers
    • Immunosuppressant Monoclonal Antibodies
    • Adjuvant Medications Used to Treat Asthma

SECTION 7 DRUGS AFFECTING THE RENAL AND DIGESTIVE SYSTEMS

    • 34 Drug Therapy for Fluid Volume Excess
    • Introduction
    • Renal Physiology
    • Overview of Conditions Requiring Diuretic Agents
    • Loop Diuretics
    • Thiazide Diuretics
    • Potassium-Sparing Diuretics
    • Adjuvant Medications Used to Treat Fluid Volume Excess
    • 35 Nutritional Support Products, Vitamins, and Mineral Supplements
    • Introduction
    • Overview of Altered Nutritional States
    • Fat-Soluble Vitamins
    • Water-Soluble Vitamins
    • Minerals
    • Nutritional Products
    • 36 Drug Therapy for Weight Management
    • Introduction
    • Overview of Weight Management
    • Noradrenergic Sympathomimetic Anorexiants
    • Lipase Inhibitors
    • Other Drugs Used for Weight Management
    • Herbal and Dietary Supplements Used for Weight Management
    • 37 Drug Therapy for Peptic Ulcer Disease and Hyperacidity
    • Introduction
    • Overview of Peptic Ulcer Disease and Gastroesophageal Reflux Disease
    • Antacids
    • Histamine2 Receptor Antagonists
    • Proton Pump Inhibitors
    • Adjuvant Medications Used to Treat Peptic Ulcer Disease and Gastroesophageal Reflux Disease
    • 38 Drug Therapy for Nausea and Vomiting
    • Introduction
    • Overview of Nausea and Vomiting
    • Phenothiazines
    • Antihistamines
    • 5-Hydroxytryptamine3 (5-HT3) or Serotonin Receptor Antagonists
    • Substance P/Neurokinin 1 Antagonists
    • Miscellaneous Antiemetics
    • Nonpharmacologic Management
    • 39 Drug Therapy for Constipation and Elimination Problems
    • Introduction
    • Overview of Constipation
    • Laxatives
    • Cathartics
    • Miscellaneous Agents for Constipation
    • 40 Drug Therapy for Diarrhea
    • Introduction
    • Overview of Diarrhea
    • Opiate-Related Antidiarrheal Agents
    • Adjuvant Medications Used to Treat Diarrhea

SECTION 8 DRUGS AFFECTING THE ENDOCRINE SYSTEM

    • 41 Drug Therapy for Diabetes Mellitus
    • Introduction
    • Overview of Diabetes
    • Insulins
    • Sulfonylureas
    • Biguanide
    • Alpha-Glucosidase Inhibitors
    • Thiazolidinediones
    • Meglitinides
    • Dipeptidyl Peptidase 4 Inhibitors
    • Amylin Analogs
    • Glucagon-Like Peptide-1 Receptor Agonists (Incretin Mimetics)
    • Sodium Glucose Cotransporter 2 (SGLT2) Inhibitors
    • Combination Drug Therapy for Type 2 Diabetes
    • Adjuvant Medications Used to Treat Diabetes
    • 42 Drug Therapy for Hyperthyroidism and Hypothyroidism
    • Introduction
    • Overview of the Thyroid Gland
    • Antithyroid Drugs
    • Adjuvant Medication Used to Treat Hyperthyroidism
    • Thyroid Drugs
    • 43 Drug Therapy for Pituitary and Hypothalamic Dysfunction
    • Introduction
    • Overview of Pituitary and Hypothalamic Dysfunction
    • Anterior Pituitary Hormone Drugs for Growth Deficiency in Children
    • Posterior Pituitary Hormone Drugs for Diabetes Insipidus
    • Hypothalamic Hormone Drugs
    • 44 Drug Therapy to Regulate Calcium and Bone Metabolism
    • Introduction
    • Overview of Calcium and Bone Metabolism
    • Calcium Preparations
    • Vitamin D
    • Bisphosphonates
    • Other Medications Used to Treat Bone Disorders and Hypercalcemia
    • 45 Drug Therapy for Adrenal Cortex Disorders
    • Introduction
    • Overview of Addison’s Disease
    • Overview of Cushing’s Disease
    • Drugs Used to Treat Addison’s Disease
    • Drugs Used to Treat Cushing’s Disease
    • Glucocorticoid Receptor Antagonists

SECTION 9 DRUGS AFFECTING THE AUTONOMIC AND CENTRAL NERVOUS SYSTEM

    • 46 Physiology of the Autonomic and Central Nervous Systems and Indications for the Use of Drug Therapy
    • Introduction
    • Structure and Function of the Autonomic Nervous System
    • Characteristics of Autonomic Drugs
    • 47 Drug Therapy for Myasthenia Gravis, Alzheimer’s Disease, and Other Conditions Treated with Cholinergic Agents
    • Introduction
    • Overview of Myasthenia Gravis
    • Acetylcholinesterase Inhibitors (Indirect-Acting Cholinergics)
    • Immunosuppressive Therapy for Myasthenia Gravis
    • Overview of Alzheimer’s Disease
    • Cholinesterase Inhibitors: Reversible Indirect-Acting Cholinergics
    • N-Methyl-d-Aspartate Receptor Antagonist
    • Cholinesterase Inhibitor–N-Methyl-d-Aspartate Receptor Antagonist
    • Overview of Urinary Retention
    • Cholinergic Agonist
    • Irreversible Anticholinesterase Toxicity
    • 48 Drug Therapy for Parkinson’s Disease, Urinary Spasticity, and Disorders Requiring Anticholinergic Drug Therapy
    • Introduction
    • Overview of Parkinson’s Disease
    • Dopamine Receptor Agonists
    • Catechol-O-Methyltransferase Inhibitors
    • Catechol-O-Methyltransferase Inhibitor and Decarboxylase Inhibitor/Dopamine Precursor
    • Overview of Anticholinergic Drugs
    • Belladonna Alkaloid and Derivatives
    • Centrally Acting Anticholinergics
    • Gastrointestinal Anticholinergics (Antisecretory/Antispasmodic)
    • Urinary Antispasmodics
    • 49 Drug Therapy With Opioids
    • Introduction
    • Overview of Impact of the Opioid Epidemic
    • Overview of Pain
    • Opioid Agonists
    • Opioid Agonists/Antagonists
    • Opioid Antagonists
    • 50 Drug Therapy With Local Anesthetics
    • Introduction
    • Overview of Local Anesthesia
    • Amides
    • Esters
    • 51 Drug Therapy With General Anesthetics
    • Introduction
    • Overview of General Anesthesia
    • Inhalation Anesthetics
    • Intravenous General Anesthetics
    • Neuromuscular Blocking Agents
    • Adjuvant Medications Used in General Anesthesia
    • 52 Drug Therapy for Migraine and Other Headaches
    • Introduction
    • Overview of Headaches
    • Nonsteroidal Anti-Inflammatory Agents
    • Acetaminophen, Aspirin, and Caffeine
    • Ergot Alkaloids
    • Triptans
    • Estrogen
    • Preventive Therapy for Migraine Headaches
    • Adjuvant Medications for Migraine Headaches
    • 53 Drug Therapy for Seizure Disorders and Skeletal Muscle Disorders
    • Introduction
    • Overview of Epilepsy
    • Drugs Used to Treat Seizure Disorders
    • Other Antiepileptic Drugs
    • Overview of Spinal Cord Injury
    • Drugs Used to Treat Muscle Spasms and Spasticity
    • 54 Drug Therapy for Anxiety and Insomnia
    • Introduction
    • Overview of Anxiety
    • Overview of Sleep and Insomnia
    • Benzodiazepines
    • Nonbenzodiazepine Sedative–Hypnotic Agents
    • 55 Drug Therapy for Depression and Mood Stabilization
    • Introduction
    • Overview of Depression
    • Overview of Bipolar Disorder
    • Tricyclic Antidepressants
    • Selective Serotonin Reuptake Inhibitors
    • Serotonin–Norepinephrine Reuptake Inhibitors
    • Monoamine Oxidase Inhibitors
    • Atypical Antidepressants
    • Mood-Stabilizing Agents: Drugs Used to Treat Bipolar Disorder
    • Other Medications Used to Treat Bipolar Disorder
    • 56 Drug Therapy for Psychotic Disorders
    • Introduction
    • Overview of Psychosis
    • First-Generation Antipsychotics
    • First-Generation Nonphenothiazines
    • Second-Generation “Atypical” Antipsychotics
    • 57 Drug Therapy for Attention Deficit Hyperactivity Disorder and Narcolepsy
    • Introduction
    • Overview of Attention Deficit Hyperactivity Disorder
    • Overview of Narcolepsy
    • Stimulants
    • Amphetamines
    • Amphetamine-Related Drugs
    • Other Medications Used to Treat Attention Deficit Hyperactivity Disorder and Narcolepsy
    • 58 Drug Therapy for Substance Use Disorders
    • Introduction
    • Overview of Substance Use
    • Central Nervous System Depressant Use: Drug Therapy
    • Benzodiazepines for Treatment of Alcohol Withdrawal
    • Enzyme Inhibitors for Maintenance of Alcohol Sobriety
    • Drugs Used to Reduce Cravings in Alcohol Use
    • Opioid Agonists and Antagonists for Treatment of Opioid Abuse
    • Central Nervous System Stimulant Abuse: Drug Therapy
    • Psychoactive Substance Use: Drug Therapy

SECTION 10 DRUGS AFFECTING THE EYE, EAR, AND SKIN

    • 59 Drug Therapy for Disorders of the Eye
    • Introduction
    • Basic Structure and Function of the Eye
    • Overview of Disorders of the Eye
    • Drug Therapy for the Diagnosis and Treatment of Ocular Disorders
    • Drug Therapy for the Treatment of Glaucoma
    • Alpha2-Adrenergic Agonists and Carbonic Anhydrase Inhibitors
    • Drug Therapy for Ocular Infections and Inflammation
    • 60 Drug Therapy for Disorders of the Ear
    • Introduction
    • Overview of Disorders of the Ear
    • Anti-infective, Antiseptic, Glucocorticoid, and Acidifying Agents
    • Fluoroquinolone: Ciprofloxacin
    • Penicillin: Amoxicillin
    • Adjuvant Medications to Treat Pain and Fever Related to Infections of the Ear
    • 61 Drug Therapy for Disorders of the Skin
    • Introduction
    • Disorders of the Skin
    • Drug Therapy
    • Retinoids

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